San Francisco 49ers vs Arizona Cardinals prediction

NFL · 2026 · Week 18January 10, 2027 · 13:00 ET
San Francisco 49ers
Arizona Cardinals
vsScheduled
Away · Home

State Farm Stadium

GidStats prediction

Our pick: San Francisco 49ers to win

The model gives the San Francisco 49ers a 63.6% chance to beat the Arizona Cardinals and projects a 3.9-point margin.

Recorded November 6, 2026, 16:30 ET.

San Francisco 49ers63.6%
Arizona Cardinals36.4%

These two-outcome estimates do not separately model ties.

Injuries and quarterback changes are not model inputs. Historical market prices were more accurate in our test. Compare the full results.

Team comparison

Regular-season averages from available weeks before this game. Later results are excluded.

Per gameSFARI
Games in sample78
Passing yards249.7239.3
Rushing yards127.4109.3
Sacks allowed1.02.5

Head-to-head

San Francisco 49ers injury report

A current injury report for this game is unavailable. This does not mean that every player is healthy.

Arizona Cardinals injury report

A current injury report for this game is unavailable. This does not mean that every player is healthy.

Where to play

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Spread and total prices are not displayed. A broadcast channel has not been confirmed.

Source: GidStats editorial team · Model and data methodology

Source: nflverse · Last successful sync November 6, 2026, 16:30 ET. Scores may be delayed.